Sync^tm1Chen
Targeted Allele Detail

Summary

• Symbol: Sync^tm1Chen
• Name: syncoilin; targeted mutation 1, Ju CHen
• MGI ID: MGI:3797113
• Gene: Sync Location: Chr4:129181410-129202352 bp, + strand Genetic Position: Chr4, 63.26 cM
• Alliance: Sync^tm1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted immediately after exon 2 altering the splice site. The absence of protein product was confirmed by western blot analysis. (J:136645)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sync Mutation: 21 strains or lines available

References

• Original: J:136645 Zhang J, et al., Syncoilin is required for generating maximum isometric stress in skeletal muscle but dispensable for muscle cytoarchitecture. Am J Physiol Cell Physiol. 2008 May;294(5):C1175-82
• All: 1 reference(s)