Ccl25^tm1.1Mal
Targeted Allele Detail

Summary

• Symbol: Ccl25^tm1.1Mal
• Name: C-C motif chemokine ligand 25; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:3797365
• Synonyms: Ccl25^tm1Mal
• Gene: Ccl25 Location: Chr8:4375210-4410020 bp, + strand Genetic Position: Chr8, 2.01 cM
• Alliance: Ccl25^tm1.1Mal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136944
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 (including the translation initiation site) and all of exons 3 and 4 were replaced with a floxed neomycin resistance gene cassette. The neo cassette was removed through subsequent germline, cre-mediated recombination. (J:136944)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl25 Mutation: 40 strains or lines available

References

• Original: J:136944 Wurbel MA, et al., Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol. 2007 Jun 15;178(12):7598-606
• All: 4 reference(s)