Tex11^tm1.1Jpt
Targeted Allele Detail

Summary

• Symbol: Tex11^tm1.1Jpt
• Name: testis expressed gene 11; targeted mutation 1.1, John H J Petrini
• MGI ID: MGI:3797590
• Synonyms: Zip4h^-
• Gene: Tex11 Location: ChrX:99882254-100103245 bp, - strand Genetic Position: ChrX, 43.72 cM
• Alliance: Tex11^tm1.1Jpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136834
• Parent Cell Line: AC1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was deleted by germ line, cre-mediated recombination. Deletion of exon three results in an aberrant splice product with a premature termination condon 6 nucleotides downstream. The absence of full length protein product was confirmed by western blot analysis on P12 testis extracts. A smaller molecular weight protein band was detected at low levels. (J:136834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex11 Mutation: 21 strains or lines available

References

• Original: J:136834 Adelman CA, et al., ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. PLoS Genet. 2008 Mar;4(3):e1000042
• All: 1 reference(s)