Timp3^tm1Hest
Targeted Allele Detail

Summary

• Symbol: Timp3^tm1Hest
• Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Heidi Stohr
• MGI ID: MGI:3797605
• Gene: Timp3 Location: Chr10:86136276-86185369 bp, + strand Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
• Alliance: Timp3^tm1Hest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136890
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 3 leading to a frame shift and the introduction of a premature stop codon. The absence of protein product was confirmed by western blot analysis on primary fibroblast extracts. (J:136890)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timp3 Mutation: 19 strains or lines available

References

• Original: J:136890 Janssen A, et al., Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2812-22
• All: 4 reference(s)