Tg(FXN)YG8Pook
Transgene Detail

Summary

• Symbol: Tg(FXN)YG8Pook
• Name: transgene insertion YG8, Mark A Pook
• MGI ID: MGI:3797739
• Synonyms: YG8
• Transgene: Tg(FXN)YG8Pook Location: unknown
• Alliance: Tg(FXN)YG8Pook page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FXN)YG8Pook expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FXN (2395)

  Fxn	(MGI:1096879)

• Mutation details: The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG8 was established, carrying 2 tandem copies of the human FXN gene with two GAA trinucleotide repeat sequences of 82 and 190 repeats. This line displayed a transmission rate of 52% to offspring. (J:91581)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available

Notes

Line YG22 exhibits slightly greater age-related repeat instability, with a bias toward repeat expansion.

References

• Original: J:91581 Al-Mahdawi S, et al., GAA repeat instability in Friedreich ataxia YAC transgenic mice. Genomics. 2004 Aug;84(2):301-10
• All: 32 reference(s)