Sost^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Sost^{tm1(KOMP)Vlcg}
• Name: sclerostin; targeted mutation 1, Velocigene
• MGI ID: MGI:3797839
• Synonyms: SostLacZ, Sost^LacZ-neo, Sost^tm1Vlcg
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^{tm1(KOMP)Vlcg} page
• IMPC: Sost gene page

Higher bone mass in Rr20^tm1.1Vlcg/Rr20^tm1.1Vlcg and Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: 10069A-G10, 10069B-C7, 10069B-C10, 10069B-E8
• Germline Transmission: Earliest citation of germline transmission: J:167585
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 3174bp between positions 101854623-101857796 of Chromosome 11 (Build GRCm39). (J:136110, J:167585)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Sost Mutation: 35 strains or lines available

Notes

Cell line 10069B-C10 was successfully used to make chimeric mice. Germline transmission was accomplished. J:188586
Cell line 10069A-G10 was successfully used to make chimeric mice. Germline transmission was accomplished. J:167585

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 20 reference(s)