Tg(Prnp-ATXN3)CVcg
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN3)CVcg
• Name: transgene insertion C, Veronica Colomer Gould
• MGI ID: MGI:3798044
• Synonyms: Q71-C
• Transgene: Tg(Prnp-ATXN3)CVcg Location: unknown
• Alliance: Tg(Prnp-ATXN3)CVcg page

Transgene origin

• Strain of Origin: C57BL/6J x C3H/HeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN3)CVcg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The mouse prion promoter drives the expression of the full-length human mutant (Q71) ataxin-3 cDNA. The transgene is expressed in brain of transgenic mice. (J:96574)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96574 Goti D, et al., A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration. J Neurosci. 2004 Nov 10;24(45):10266-79
• All: 4 reference(s)