Runx1^tm2Buch
Targeted Allele Detail

Summary

• Symbol: Runx1^tm2Buch
• Name: runt related transcription factor 1; targeted mutation 2, Frank Buchholz
• MGI ID: MGI:3798051
• Synonyms: AML1^f
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm2Buch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105709
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin targeting cassette was placed downstream of exon 5 and a loxP site was placed upstream of exon 5. Correct targeting was confirmed through genomic PCR. (J:105709)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:105709 Putz G, et al., AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene. 2006 Feb 9;25(6):929-39
• All: 9 reference(s)