Del(5D5Mit73-D5Mit351)5Jcs
Radiation induced Allele Detail

Summary

• Symbol: Del(5D5Mit73-D5Mit351)5Jcs
• Name: deletion, Chr 5, John C. Schimenti 5; deletion, Chr 5, John C Schimenti 5
• MGI ID: MGI:3798174
• Synonyms: Del5Jcs, Hdh^df4J
• Gene: Del(5D5Mit73-D5Mit351)5Jcs Location: Chr5:26805985-37176464 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63451
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Del(5D5Mit73-D5Mit351)5Jcs involves 239 genes/genome features (Gm20671, Gm19446, Gm2183 ...) View all
• Mutation details: Targeted insertion of thymidine kinase into the C57BL/6J derived Chromosome 5 Htt locus in the v6.4 ES cell line was followed by 400 Gy of gamma radiation, FIAU selection, and injection into C57BL/6J blastocysts. The deletion includes the full Wolf-Hirschhorn syndrome critical region. (J:63451)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5D5Mit73-D5Mit351)5Jcs Mutation: 0 strains or lines available

References

• Original: J:63451 Schimenti JC, et al., Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells. Genome Res. 2000 Jul;10(7):1043-50
• All: 5 reference(s)