Spta1^sph-4J
Chemically induced Allele Detail

Summary

• Symbol: Spta1^sph-4J
• Name: spectrin alpha, erythrocytic 1; spherocytosis 4 Jackson
• MGI ID: MGI:3798219
• Synonyms: nmf4
• Gene: Spta1 Location: Chr1:174000342-174076016 bp, + strand Genetic Position: Chr1, 80.97 cM
• Alliance: Spta1^sph-4J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: A guanine to adenine transversion in exon 52 results in a cysteine to tyrosine substitution in the C-terminal EF Hand domain (C2384Y). (J:157766)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spta1 Mutation: 147 strains or lines available

References

• Original: J:157766 Robledo RF, et al., Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in {alpha}-spectrin-deficient red cells. Blood. 2010 Mar 4;115(9):1804-14
• All: 1 reference(s)