Grip1^tm1Rlh
Targeted Allele Detail

Summary

• Symbol: Grip1^tm1Rlh
• Name: glutamate receptor interacting protein 1; targeted mutation 1, Richard L Huganir
• MGI ID: MGI:3798437
• Synonyms: GRIP1^flox
• Gene: Grip1 Location: Chr10:119289810-119923172 bp, + strand Genetic Position: Chr10, 67.33 cM, cytoband D2
• Alliance: Grip1^tm1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136388
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the first coding exon and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of this exon. Germ line, flp-mediated recombination was used to remove the neo cassette leaving the first coding exon floxed. (J:136388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grip1 Mutation: 93 strains or lines available

References

• Original: J:136388 Takamiya K, et al., The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells. J Neurosci. 2008 May 28;28(22):5752-5
• All: 9 reference(s)