Tbx6^tm2Pa
Targeted Allele Detail

Summary

• Symbol: Tbx6^tm2Pa
• Name: T-box 6; targeted mutation 2, Virginia Papaioannou
• MGI ID: MGI:3798467
• Synonyms: Tbx6^{tm2(HIST1H2BB/EYFP)Pa}
• Gene: Tbx6 Location: Chr7:126380655-126384720 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Tbx6^tm2Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137163
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exon 2 and part of exon 3 were replaced with an human HIST1H2BB-EYFP fusion in frame with exon 1. (J:137163)

Expression

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx6 Mutation: 17 strains or lines available

References

• Original: J:137163 Hadjantonakis AK, et al., Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One. 2008;3(6):e2511
• All: 4 reference(s)