Opn4^tm1(cre)Sapa
Targeted Allele Detail

Summary

• Symbol: Opn4^tm1(cre)Sapa
• Name: opsin 4 (melanopsin); targeted mutation 1, Satchidananda Panda
• MGI ID: MGI:3798479
• Synonyms: mOpn4-Cre1D4, Opn4^Cre
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^tm1(cre)Sapa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Opn4^tm1(cre)Sapa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Opn4 (MGI:1353425)

• Mutation details: The first 7 exons were replaced with a cassette containing a cre gene, IRES/betaTau, a floxed neo and eYFP gene. No YFP expression was detected in the retina. Cre activity is detected in the retinal ganglion cell layer. (J:137151)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Opn4 (mouse) Summary of all recombinase alleles driven by Opn4. Comparative matrix view of recombinase activities Alliance mouse Opn4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 33 strains or lines available

References

• Original: J:137151 Hatori M, et al., Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One. 2008;3(6):e2451
• All: 9 reference(s)