Kdm5a^tm1.1Kael
Targeted Allele Detail

Summary

• Symbol: Kdm5a^tm1.1Kael
• Name: lysine demethylase 5A; targeted mutation 1.1, William G Kaelin
• MGI ID: MGI:3798768
• Gene: Kdm5a Location: Chr6:120341085-120421535 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Kdm5a^tm1.1Kael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137185
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was generated by flanking exons 5 and 6 with a 5' loxP site and a 3' Frt-PGK-neomycin-Frt-LoxP expression cassette. Germline transmitting mice were bred sequentially with CAGG-Flpe mice to remove the neo cassette, and then to EIIa-Cre transgenic mice in FVB background to generate the null allele. (J:137185)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kdm5a^tm1.1Kael

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm5a Mutation: 76 strains or lines available

References

• Original: J:137185 Klose RJ, et al., The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007 Mar 9;128(5):889-900
• All: 7 reference(s)