Mta2^tm1.1Yzha
Targeted Allele Detail

Summary

• Symbol: Mta2^tm1.1Yzha
• Name: metastasis-associated gene family, member 2; targeted mutation 1.1, Yi Zhang
• MGI ID: MGI:3798815
• Synonyms: Mta2^1lox, Mta2^delta
• Gene: Mta2 Location: Chr19:8919239-8929659 bp, + strand Genetic Position: Chr19, 6.04 cM, cytoband B
• Alliance: Mta2^tm1.1Yzha page

Adult Mta2^tm1.1Yzha/Mta2^tm1.1Yzha mice exhibit autoimmunity-related phenotypes in multiple organs

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137101
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and exons 4 through 11. The absence of protein product was confirmed by western blot analysis on liver extracts. (J:137101)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mta2 Mutation: 38 strains or lines available

References

• Original: J:137101 Lu X, et al., Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem. 2008 May 16;283(20):13825-33
• All: 2 reference(s)