Adcy1^tm1.1Ito
Targeted Allele Detail

Summary

• Symbol: Adcy1^tm1.1Ito
• Name: adenylate cyclase 1; targeted mutation 1.1, Shigeyoshi Itohara
• MGI ID: MGI:3798842
• Synonyms: AC1^delta
• Gene: Adcy1 Location: Chr11:7013489-7128506 bp, + strand Genetic Position: Chr11, 4.72 cM, cytoband A2
• Alliance: Adcy1^tm1.1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137123
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exon 1. The absence of transcript expression was confirmed by RT-PCR on brain extracts. (J:137123)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adcy1 Mutation: 73 strains or lines available

References

• Original: J:137123 Iwasato T, et al., Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci. 2008 Jun 4;28(23):5931-43
• All: 3 reference(s)