Gli3^tm1.1Alj
Targeted Allele Detail

Summary

• Symbol: Gli3^tm1.1Alj
• Name: GLI-Kruppel family member GLI3; targeted mutation 1.1, Alexandra L Joyner
• MGI ID: MGI:3798850
• Synonyms: Gli3^rec
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm1.1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137136
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exon 8 leading to a frameshift mutation upstream of the DNA binding domain. (J:137136)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:137136 Blaess S, et al., Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
• All: 2 reference(s)