Pkp3^tm1.1Fvr
Targeted Allele Detail

Summary

• Symbol: Pkp3^tm1.1Fvr
• Name: plakophilin 3; targeted mutation 1.1, Frans van Roy
• MGI ID: MGI:3798862
• Gene: Pkp3 Location: Chr7:140658202-140670424 bp, + strand Genetic Position: Chr7, 86.34 cM, cytoband F5
• Alliance: Pkp3^tm1.1Fvr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136451
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 2-4. The absence of protein product was confirmed by western blot analysis on skin extracts. (J:136451)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkp3 Mutation: 30 strains or lines available

References

• Original: J:136451 Sklyarova T, et al., Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 2008 Jun;128(6):1375-85
• All: 3 reference(s)