Fbxw7^tm1Iaai
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1Iaai
• Name: F-box and WD-40 domain protein 7; targeted mutation 1, Iannis Aifantis
• MGI ID: MGI:3798866
• Synonyms: Fbw7^flox
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 4 and an FRT and loxP site flanked neomycin resistance gene cassette was inserted onto intron 6. Flp-mediated recombination was used to remove the neo cassette leaving exons 5 and 6 floxed. (J:137138)

Expression

In Mice Carrying this Mutation:	149 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fbxw7^tm1Iaai

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:137138 Thompson BJ, et al., Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med. 2008 Jun 9;205(6):1395-408
• All: 25 reference(s)