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Fbxw7tm1Iaai
Targeted Allele Detail
Summary
Symbol: Fbxw7tm1Iaai
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Iannis Aifantis
MGI ID: MGI:3798866
Synonyms: Fbw7flox
Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance: Fbxw7tm1Iaai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137138
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv x C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 4 and an FRT and loxP site flanked neomycin resistance gene cassette was inserted onto intron 6. Flp-mediated recombination was used to remove the neo cassette leaving exons 5 and 6 floxed. (J:137138)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 149 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Fbxw7tm1Iaai
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  84 strains or lines available
References
Original:  J:137138 Thompson BJ, et al., Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med. 2008 Jun 9;205(6):1395-408
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory