Igs7^{tm1(tetO-Apoe)Gaga}
Targeted Allele Detail

Summary

• Symbol: Igs7^{tm1(tetO-Apoe)Gaga}
• Name: intergenic site 7; transgene insertion 1, George A Gaitanaris
• MGI ID: MGI:3798884
• Synonyms: Iis7^{tm1(tetO-Apoe)Gaga}, T1, Tg(tetO-Apoe)1Gaga, TRE-Apoe
• Gene: Igs7 Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Igs7^{tm1(tetO-Apoe)Gaga} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136987
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, RMCE-ready)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Igs7^{tm1(tetO-Apoe)Gaga} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apoe (MGI:88057)

• Mutation details: Retroviral insertion of a transgene carrying a neo cassette with a 5' loxP site was used to create the TIGRE loci at chromosome 9 qA3 between AB124611 and Carm1. Cre-mediated cassette exchange was used to introduce a Apoe gene with a 5' loxP site prior to the neo cassette. The Apoe gene is inducible and floxed. (J:136987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs7 Mutation: 66 strains or lines available

References

• Original: J:136987 Zeng H, et al., An inducible and reversible mouse genetic rescue system. PLoS Genet. 2008 May;4(5):e1000069
• All: 1 reference(s)