Oca2^p-226THO-I
Radiation induced Allele Detail

Summary

• Symbol: Oca2^p-226THO-I
• Name: oculocutaneous albinism II; pink-eyed dilution 226THO-I
• MGI ID: MGI:3798908
• Synonyms: Oca2^p-50R, p^226THO-I
• Gene: Oca2 Location: Chr7:55889508-56186266 bp, + strand Genetic Position: Chr7, 33.44 cM
• Alliance: Oca2^p-226THO-I page

Mutation origin

• Strain of Origin: (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Deletion
• Oca2^p-226THO-I involves 1 genes/genome features (Gabra5) View all
• Mutation details: Radiation mutagenesis induced a deletion in the pink-eyed dilution locus that includes deletion of Gabra5 and while the Gabra3 gene is still detected no Gabra3 transcript is observed. (J:12553)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oca2 Mutation: 70 strains or lines available

Notes

Distal breakpoint shown in Fig.1 of Dhar & Johnson (1997) is in error. It should be between Gabra5 and Gabrb3. No Gabrb3 transcript detected. (J:100221)

References

• Original: J:12553 Culiat CT, et al., Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the beta 3 subunit of the type A gamma-aminobutyric acid receptor. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5105-9
• All: 3 reference(s)