Canx^tm1.1Osb
Targeted Allele Detail

Summary

• Symbol: Canx^tm1.1Osb
• Name: calnexin; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:3798916
• Synonyms: Canx^-, Canx^tm1.1Maik, tm1c
• Gene: Canx Location: Chr11:50184788-50216500 bp, - strand Genetic Position: Chr11, 30.46 cM
• Alliance: Canx^tm1.1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136971
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were flanked by loxP sites and subsequently deleted by cre-mediated recombination. No protein was detected in MEFs from homozygous mutant mice using antibodies against the N- and C- terminal residues. (J:250114)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Canx Mutation: 55 strains or lines available

References

• Original: J:136971 Okiyoneda T, et al., Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR. Biochim Biophys Acta. 2008 Sep;1783(9):1585-94
• All: 2 reference(s)