Tg(APOE-NPC1L1)20Lqyu
Transgene Detail

Summary

• Symbol: Tg(APOE-NPC1L1)20Lqyu
• Name: transgene insertion 20, Liqing Yu
• MGI ID: MGI:3799059
• Synonyms: L1-Tg20, NPC1L1^LiverTg, NPCL1-Tg-Mod
• Transgene: Tg(APOE-NPC1L1)20Lqyu Location: unknown
• Alliance: Tg(APOE-NPC1L1)20Lqyu page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-NPC1L1)20Lqyu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NPC1L1 (29881)

  Npc1l1

  (MGI:2685089)

• Mutation details: A transgenic construct containing the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region was injected into fertilized B6D2F1/Hsd mouse eggs. Two lines were established, L1-Tg20 and L1-Tg112. Transgene expression is detected in liver by Western blot analysis and is localized to the canalicular membrane. (J:124193)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:124193 Temel RE, et al., Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul;117(7):1968-78
• All: 6 reference(s)