About   Help   FAQ
Tg(APOE-NPC1L1)20Lqyu
Transgene Detail
Summary
Symbol: Tg(APOE-NPC1L1)20Lqyu
Name: transgene insertion 20, Liqing Yu
MGI ID: MGI:3799059
Synonyms: L1-Tg20, NPC1L1LiverTg, NPCL1-Tg-Mod
Transgene: Tg(APOE-NPC1L1)20Lqyu  Location: unknown  
Alliance: Tg(APOE-NPC1L1)20Lqyu page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(APOE-NPC1L1)20Lqyu expresses 1 gene
 
Mutation detailsA transgenic construct containing the human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1) gene under the control of the human apolipoprotein E (APOE) promoter and hepatic control region was injected into fertilized B6D2F1/Hsd mouse eggs. Two lines were established, L1-Tg20 and L1-Tg112. Transgene expression is detected in liver by Western blot analysis and is localized to the canalicular membrane. (J:124193)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:124193 Temel RE, et al., Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest. 2007 Jul;117(7):1968-78
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory