Nup133^{Gt(RRK090)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Nup133^{Gt(RRK090)Byg}
• Name: nucleoporin 133; gene trap RRK090, BayGenomics
• MGI ID: MGI:3799269
• Synonyms: Nup133^GT
• Gene: Nup133 Location: Chr8:124623862-124676004 bp, - strand Genetic Position: Chr8, 72.27 cM
• Alliance: Nup133^{Gt(RRK090)Byg} page

Mutation origin

• Mutant Cell Line: RRK090
• Germline Transmission: Earliest citation of germline transmission: J:137199
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 5. Very low expression of the full length transcript was confirmed by western blot analysis on E9.5 whole embryo extracts. (J:137199)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRK090	CC894173 ; (MGI Seq Detail)	5' RACE	Chr8:124665781-124665914 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup133 Mutation: 58 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:137199 Lupu F, et al., Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
• All: 2 reference(s)