Rfx4^m269Asp
Chemically induced Allele Detail

Summary

• Symbol: Rfx4^m269Asp
• Name: regulatory factor X, 4 (influences HLA class II expression); mutation 269, Andrew S Peterson
• MGI ID: MGI:3799278
• Synonyms: Rfx4^L298P, Rfx4^line269
• Gene: Rfx4 Location: Chr10:84591926-84742402 bp, + strand Genetic Position: Chr10, 41.63 cM, cytoband C1
• Alliance: Rfx4^m269Asp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced nucleotide transition that resulted in an amino acid substitution of proline for leucine in the C dimerization domain. (J:136795)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx4 Mutation: 48 strains or lines available

References

• Original: J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
• All: 2 reference(s)