Ppp1r1b^tm4Pggd
Targeted Allele Detail

Summary

• Symbol: Ppp1r1b^tm4Pggd
• Name: protein phosphatase 1, regulatory inhibitor subunit 1B; targeted mutation 4, Paul Greengard
• MGI ID: MGI:3799291
• Synonyms: Ser97A-DARPP-32, Ser97-DARPP-32
• Gene: Ppp1r1b Location: Chr11:98239232-98248622 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Ppp1r1b^tm4Pggd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Serine 97 was replaced with an alanine to prevent phosphorylation. (J:107305)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r1b Mutation: 18 strains or lines available

References

• Original: J:106270 Zhang Y, et al., Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. J Neurosci. 2006 Mar 8;26(10):2645-51
• All: 3 reference(s)