Tradd^tm1.1Mpa
Targeted Allele Detail

Summary

• Symbol: Tradd^tm1.1Mpa
• Name: TNFRSF1A-associated via death domain; targeted mutation 1.1, Manolis Pasparakis
• MGI ID: MGI:3799300
• Gene: Tradd Location: Chr8:105985207-105991226 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tradd^tm1.1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139030
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.4 kb fragment including all coding exons (exons 2- 5) was flanked with loxP sites and an adenoviral splice acceptor site fused to a cDNA encoding eGFP was inserted downstream of the second loxP site. In vivo cre-mediated recombination resulted in deletion of exons 2-5 and expression of eGFP under control of the endogenous promoter. (J:139030)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tradd Mutation: 18 strains or lines available

References

• Original: J:139030 Ermolaeva MA, et al., Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008 Sep;9(9):1037-46
• All: 3 reference(s)