Pcnt^m239Asp
Chemically induced Allele Detail

Summary

• Symbol: Pcnt^m239Asp
• Name: pericentrin (kendrin); mutation 239, Andrew S Peterson
• MGI ID: MGI:3799303
• Gene: Pcnt Location: Chr10:76187097-76278620 bp, - strand Genetic Position: Chr10, 38.8 cM
• Alliance: Pcnt^m239Asp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Intragenic deletion
• Mutation details: ENU mutagenesis induces a two base pair deletion in exon 31. The resulting frame shift disrupts all three isoforms with isoform A containning 46 and isoforms B and S containing 43 novel amino acids before premature truncation. The absence of the 330 KDa and 250 KDa isoforms was confirmed by western blot analysis on E14.5 brain extracts.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcnt Mutation: 159 strains or lines available

References

• Original: J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
• All: 2 reference(s)