Plec^tm5Gwi
Targeted Allele Detail

Summary

• Symbol: Plec^tm5Gwi
• Name: plectin; targeted mutation 5, Gerhard Wiche
• MGI ID: MGI:3799314
• Synonyms: ple1d^-
• Gene: Plec Location: Chr15:76055174-76115578 bp, - strand Genetic Position: Chr15, 35.48 cM
• Alliance: Plec^tm5Gwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137067
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1d was replaced with a floxed neo cassette. The absence of transcripts containing exon 1d was confirmed by RNase protection assay. (J:137067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plec Mutation: 174 strains or lines available

References

• Original: J:137067 Konieczny P, et al., Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms. J Cell Biol. 2008 May 19;181(4):667-81
• All: 2 reference(s)