Sox5^tm2Vlf
Targeted Allele Detail

Summary

• Symbol: Sox5^tm2Vlf
• Name: SRY (sex determining region Y)-box 5; targeted mutation 2, Veronique Lefebvre
• MGI ID: MGI:3799354
• Synonyms: Sox5^fl+
• Gene: Sox5 Location: Chr6:143774151-144727703 bp, - strand Genetic Position: Chr6, 76.14 cM
• Alliance: Sox5^tm2Vlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137217
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon CE5 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon CE5. Germ line, flp-mediated recombination was use remove the neo cassette leaving exon 5 floxed. (J:137217)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox5 Mutation: 45 strains or lines available

References

• Original: J:137217 Dy P, et al., Generation of mice harboring a Sox5 conditional null allele. Genesis. 2008 Jun;46(6):294-9
• All: 10 reference(s)