Klf3^tm1Merc
Targeted Allele Detail

Summary

• Symbol: Klf3^tm1Merc
• Name: Kruppel-like transcription factor 3 (basic); targeted mutation 1, Merlin Crossley
• MGI ID: MGI:3799368
• Synonyms: Klf3^-
• Gene: Klf3 Location: Chr5:64960864-64990246 bp, + strand Genetic Position: Chr5, 33.49 cM
• Alliance: Klf3^tm1Merc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The two exons encoding the zinc finger region were replaced with a neo cassette. The absence of full length protein product was confirmed by western blot analysis on spleen extracts. (J:137267)

Expression

In Mice Carrying this Mutation:	4 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Klf3 Mutation: 80 strains or lines available

References

• Original: J:137267 Sue N, et al., Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol. 2008 Jun;28(12):3967-78
• All: 13 reference(s)