Add1^tm1Llp
Targeted Allele Detail

Summary

• Symbol: Add1^tm1Llp
• Name: adducin 1; targeted mutation 1, Luanne Peters
• MGI ID: MGI:3799499
• Gene: Add1 Location: Chr5:34731008-34789652 bp, + strand Genetic Position: Chr5, 17.9 cM
• Alliance: Add1^tm1Llp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138919
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 10, 11 and 12 and their intervening introns have been replaced by a neomycin resistance cassette.
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Add1 Mutation: 372 strains or lines available

References

• Original: J:138919 Robledo RF, et al., Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood. 2008 Nov 15;112(10):4298-307
• All: 4 reference(s)