Lrfn4^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Lrfn4^{tm1(KOMP)Vlcg}
• Name: leucine rich repeat and fibronectin type III domain containing 4; targeted mutation 1, Velocigene
• MGI ID: MGI:3799757
• Synonyms: Lrfn4^tm1Vlcg, Salm3^-
• Gene: Lrfn4 Location: Chr19:4661813-4665695 bp, - strand Genetic Position: Chr19, 4.07 cM
• Alliance: Lrfn4^{tm1(KOMP)Vlcg} page
• IMPC: Lrfn4 gene page

Mutation origin

• Mutant Cell Lines: 10115A-A2, 10115A-A9, 10115A-A11, 10115A-B2, 10115A-B8, 10115A-D7
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2445bp between positions 4612057-4614501 of Chromosome 19 (Genome Build37). All coding exons (exons 2 and 3) were replaced with a beta-geo cassette (beta-galactosidase/neomycin fusion). The encoded protein was undetectable in immunoblots of whole-brain lysates derived from homozygous mutant mice. (J:136110, J:233980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Lrfn4 Mutation: 22 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)