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Hsd17b1tm1(KOMP)Vlcg
Targeted Allele Detail
Summary
Symbol: Hsd17b1tm1(KOMP)Vlcg
Name: hydroxysteroid (17-beta) dehydrogenase 1; targeted mutation 1, Velocigene
MGI ID: MGI:3799948
Synonyms: Hsd17b1tm1Vlcg
Gene: Hsd17b1  Location: Chr11:100969237-100971353 bp, + strand  Genetic Position: Chr11, 64.17 cM
Alliance: Hsd17b1tm1(KOMP)Vlcg page
IMPC: Hsd17b1 gene page
Mutation
origin
Mutant Cell Lines:  10231B-A2, 10231B-F1, 10231B-G7, 10231B-H6, 10231B-H9, 10231B-H11
Germline Transmission:  Earliest citation of germline transmission: J:188991
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1829bp between positions 100939740-100941568 of Chromosome 11 (Genome Build37). The conding sequence is completely replaced with a lacZ/neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in ovaries. (J:136110, J:225533)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Hsd17b1 Mutation:  14 strains or lines available
Notes
Cell line 10231B-H11 was successfully used to make chimeric mice. Germline transmission was/was not accomplished. J:225533
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory