Tg(MtTGFA)Lmb
Transgene Detail

Summary

• Symbol: Tg(MtTGFA)Lmb
• Name: transgene insertion, Glenn Merlino
• MGI ID: MGI:3800163
• Transgene: Tg(MtTGFA)Lmb Location: unknown
• Alliance: Tg(MtTGFA)Lmb page

Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4^tm1.1Gsu/Smad4^tm1.1Gsu Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺ Tg(MtTGFA)Lmb/0 (STP) mice

Show the 5 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MtTGFA)Lmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFA (7039)

  Tgfa	(MGI:98724)

• Mutation details: This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Two lines (100 and 42) with 100 and 42 copies of the transgene, respectively, were created. When line number is not designated this allele is used. (J:28452)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
• All: 3 reference(s)