Tg(Gfap-Il6)G369Lms
Transgene Detail

Summary

• Symbol: Tg(Gfap-Il6)G369Lms
• Name: transgene insertion G369, Lennart Mucke
• MGI ID: MGI:3800178
• Transgene: Tg(Gfap-Il6)G369Lms Location: unknown
• Alliance: Tg(Gfap-Il6)G369Lms page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gfap-Il6)G369Lms expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il6 (MGI:96559)

• Mutation details: The Gfap promoter was used to drive cerebral expression of Il6. Several lines were created including lines G369, G16, and G167. G16 founder contains both the transgene and another transgene expressing lacZ under the control of Gfap whereas G26 and G36 founders do not. This line carried eight copies of the IL-6 transgene. (J:125549)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125549 Campbell IL, et al., Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10061-5
• All: 5 reference(s)