Ccdc42^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Ccdc42^{tm1(KOMP)Vlcg}
• Name: coiled-coil domain containing 42; targeted mutation 1, Velocigene
• MGI ID: MGI:3800251
• Synonyms: Ccdc42^KO, Ccdc42^tm1Vlcg
• Gene: Ccdc42 Location: Chr11:68477863-68488777 bp, + strand Genetic Position: Chr11, 41.85 cM
• Alliance: Ccdc42^{tm1(KOMP)Vlcg} page
• IMPC: Ccdc42 gene page

Mutation origin

• Mutant Cell Lines: 10362A-D12, 10362A-F2, 10362B-D2
• Germline Transmission: Earliest citation of germline transmission: J:231668
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 10697bp between positions 68400713-68411409 of Chromosome 11 (Genome Build37). All seven exons (i.e. the entire coding sequence of the gene) were replaced with a lacZ reporter and neomycin resistance cassette. (J:136110, J:231668)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Ccdc42 Mutation: 23 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)