Stim1^{Gt(RRS558)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Stim1^{Gt(RRS558)Byg}
• Name: stromal interaction molecule 1; gene trap RRS558, BayGenomics
• MGI ID: MGI:3800290
• Synonyms: Stim1^gt, STIM1-lacZ
• Gene: Stim1 Location: Chr7:101917013-102086526 bp, + strand Genetic Position: Chr7, 54.71 cM
• Alliance: Stim1^{Gt(RRS558)Byg} page

Mutation origin

• Mutant Cell Line: RRS558
• Germline Transmission: Earliest citation of germline transmission: J:137364
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector containing a beta-geo cassette was inserted into intron 7. The absence of protein product was confirmed by western blot analysis on platelet extracts. (J:137364)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRS558	CG887220 ; (MGI Seq Detail)	5' RACE	Chr7:102070566-102070733 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  7 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stim1 Mutation: 47 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:137364 Varga-Szabo D, et al., The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med. 2008 Jul 7;205(7):1583-91
• All: 16 reference(s)