Il21r^tm1Kopf
Targeted Allele Detail

Summary

• Symbol: Il21r^tm1Kopf
• Name: interleukin 21 receptor; targeted mutation 1, Manfred Kopf
• MGI ID: MGI:3800291
• Synonyms: Il-21r^-
• Gene: Il21r Location: Chr7:125202601-125232742 bp, + strand Genetic Position: Chr7, 68.98 cM, cytoband F4
• Alliance: Il21r^tm1Kopf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137508
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR on splenocyte extracts. (J:137508)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il21r Mutation: 42 strains or lines available

References

• Original: J:137508 Frohlich A, et al., IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood. 2007 Mar 1;109(5):2023-31
• All: 28 reference(s)