Mcl1^tm1Ywh
Targeted Allele Detail

Summary

• Symbol: Mcl1^tm1Ywh
• Name: myeloid cell leukemia sequence 1; targeted mutation 1, You-Wen He
• MGI ID: MGI:3800294
• Synonyms: Mcl-1^fl
• Gene: Mcl1 Location: Chr3:95566099-95570487 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Mcl1^tm1Ywh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137502
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A lox P site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:137502)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcl1 Mutation: 35 strains or lines available

References

• Original: J:137502 Dzhagalov I, et al., The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood. 2007 Feb 15;109(4):1620-6
• All: 18 reference(s)