Map3k10^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Map3k10^tm1Lex
• Name: mitogen-activated protein kinase kinase kinase 10; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3800582
• Synonyms: Mlk2^-
• Gene: Map3k10 Location: Chr7:27355800-27374023 bp, - strand Genetic Position: Chr7, 15.95 cM
• Alliance: Map3k10^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137358
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a beta-galactosidase and neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:137358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k10 Mutation: 34 strains or lines available

References

• Original: J:137358 Bisson N, et al., Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Cell Cycle. 2008 Apr;7(7):909-16
• All: 1 reference(s)