Fzr1^tm1Mama
Targeted Allele Detail

Summary

• Symbol: Fzr1^tm1Mama
• Name: fizzy and cell division cycle 20 related 1; targeted mutation 1, Marcos Malumbres
• MGI ID: MGI:3800718
• Synonyms: Cdh1^fl, Frz1^loxp, Fzr1^flox
• Gene: Fzr1 Location: Chr10:81202713-81214204 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Fzr1^tm1Mama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 2 and 3 floxed. (J:137456)

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzr1 Mutation: 43 strains or lines available

References

• Original: J:137456 Garcia-Higuera I, et al., Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol. 2008 Jul;10(7):802-11
• All: 21 reference(s)