Zap70^m6Hefl
Chemically induced Allele Detail

Summary

• Symbol: Zap70^m6Hefl
• Name: zeta-chain (TCR) associated protein kinase; mutation 6, Heinrich Flaswinkel
• MGI ID: MGI:3800788
• Synonyms: TUM079, Zap70^deltaT3
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^m6Hefl page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a transition of A to G leading to an amino acid substitution of glycine for glutamic acid at position 589 (E589G) in the kinase domain. Reduced protein expression was confirmed by western blot analysis on CD4+CD8+ thymocytes. This is a hypomorphic allele. (J:137446)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:137446 Jakob T, et al., Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. J Allergy Clin Immunol. 2008 Jan;121(1):179-184.e7
• All: 1 reference(s)