Oxtr^tm1Wsy
Targeted Allele Detail

Summary

• Symbol: Oxtr^tm1Wsy
• Name: oxytocin receptor; targeted mutation 1, W Scott Young III
• MGI ID: MGI:3800795
• Synonyms: Oxtr^Neo
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^tm1Wsy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137445
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted downstream of exon 3. Autoradiography with 125-I labeled ornithine vasotocin, an Oxt antagonist, confirmed decreased endogenous and ectopic protein expression. (J:137445)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 41 strains or lines available

References

• Original: J:137445 Lee HJ, et al., A conditional knockout mouse line of the oxytocin receptor. Endocrinology. 2008 Jul;149(7):3256-63
• All: 2 reference(s)