Ranbp2^tm1.1Jvd
Targeted Allele Detail

Summary

• Symbol: Ranbp2^tm1.1Jvd
• Name: RAN binding protein 2; targeted mutation 1.1, Jan M A van Deursen
• MGI ID: MGI:3800899
• Gene: Ranbp2 Location: Chr10:58282674-58329977 bp, + strand Genetic Position: Chr10, 29.34 cM
• Alliance: Ranbp2^tm1.1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137482
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exon 3. Lack of protein expression from this allele was confirmed by western blot analysis on heterozygous mouse embryonic fibroblast extracts. (J:137482)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ranbp2^tm1.1Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ranbp2 Mutation: 115 strains or lines available

References

• Original: J:137482 Dawlaty MM, et al., Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008 Apr 4;133(1):103-15
• All: 2 reference(s)