Slc6a4^tm1(tTA)Cogr
Targeted Allele Detail

Summary

• Symbol: Slc6a4^tm1(tTA)Cogr
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Cornelius Gross
• MGI ID: MGI:3800924
• Synonyms: Slc6a4^tTA
• Gene: Slc6a4 Location: Chr11:76889429-76923166 bp, + strand Genetic Position: Chr11, 46.18 cM
• Alliance: Slc6a4^tm1(tTA)Cogr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137439
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Transactivator)
• Mutation: Insertion
• Mutation details: A cassette containing the tetracycline trans-activator and a floxed neo were knocked into exon 2 at the translation initiation codon. In situ hybridization and autoradiography were used to confirm the absence of transcript and protein expression. (J:137439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a4 Mutation: 53 strains or lines available

References

• Original: J:137439 Audero E, et al., Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul 4;321(5885):130-3
• All: 3 reference(s)