Fmn1^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Fmn1^tm1Awb
• Name: formin 1; targeted mutation 1, Anthony Wynshaw-Boris
• MGI ID: MGI:3800994
• Synonyms: ld^GKO
• Gene: Fmn1 Location: Chr2:113158081-113547112 bp, + strand Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
• Alliance: Fmn1^tm1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43337
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-neo cassette was inserted 195 bp 3' of the start codon of the 5'-terminal exon of isoform IV (exon 6) and stop codons were introduced in all 3 reading frames. Immunoblot analysis failed to detect isoform IV in adult kidney and E10.5 whole body lysates. (J:43337)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmn1 Mutation: 76 strains or lines available

References

• Original: J:43337 Wynshaw-Boris A, et al., The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol Med. 1997 Jun;3(6):372-84
• All: 2 reference(s)