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Cul7tm1Zqp
Targeted Allele Detail
Summary
Symbol: Cul7tm1Zqp
Name: cullin 7; targeted mutation 1, Zhen-Qiang Pan
MGI ID: MGI:3801047
Gene: Cul7  Location: Chr17:46961264-46975290 bp, + strand  Genetic Position: Chr17, 22.9 cM
Alliance: Cul7tm1Zqp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137062
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced exons 2-4 such that the translation initiation site located in exon 2 was disrupted via homologous recombination. By immunoblot, no protein was detected in MEF isolated from homozygous null embryos. (J:137062)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cul7 Mutation:  72 strains or lines available
References
Original:  J:137062 Xu X, et al., The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell. 2008 May 23;30(4):403-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory