Ackr3^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Ackr3^tm1Litt
• Name: atypical chemokine receptor 3; targeted mutation 1, Dan R Littman
• MGI ID: MGI:3801080
• Synonyms: CXCR7^GFP, Cxcr7^tm1(GFP)Litt
• Gene: Ackr3 Location: Chr1:90131702-90143446 bp, + strand Genetic Position: Chr1, 45.28 cM
• Alliance: Ackr3^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: EGFP (enhanced green fluorescent protein) cDNA was knocked into the second exon of the gene immediately after the endogenous start codon. A loxP-flanked neomycin resistance cassette was also inserted right after the EGFP sequence. The targeting vector was introduced to an embryonic stem cell line derived from albino C57BL/6 mice. A cross with a C57BL/6 background EIIa-Cre mouse excised the neomycin cassette. (J:156990)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ackr3 Mutation: 34 strains or lines available

References

• Original: J:156990 Littman DR, Generation of a Cxcr7 reporter allele. MGI Direct Data Submission. 2010
• All: 12 reference(s)