Palb2^{Gt(CG0691)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Palb2^{Gt(CG0691)Wtsi}
• Name: partner and localizer of BRCA2; gene trap CG0691, Wellcome Trust Sanger Institute
• MGI ID: MGI:3801303
• Synonyms: Palb2^GT
• Gene: Palb2 Location: Chr7:121706485-121732203 bp, - strand Genetic Position: Chr7, 65.42 cM
• Alliance: Palb2^{Gt(CG0691)Wtsi} page

Mutation origin

• Mutant Cell Line: CG0691
• Germline Transmission: Earliest citation of germline transmission: J:161528
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxrT2
• Mutation details: The gene trap vector inserted into intron 1 resulting in the production of an exon 1 - beta-gal fusion protein. Quantitative RT-PCR confirmed the absence of expression in homozygous embryos. (J:161528)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  CG0691	CZ444640 ; (MGI Seq Detail)	5' RACE	Chr7:121731942-121732140 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Palb2^{Gt(CG0691)Wtsi}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Palb2 Mutation: 50 strains or lines available

References

• Original: J:161528 Rantakari P, et al., Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
• All: 3 reference(s)